Ace high-school student Fuutarou Uesugi leads an otherwise tough life. His standoffish personality and reclusive nature have left him friendless, and his father is debt-ridden, forcing his family to scrape by. One day during his lunch break, Uesugi argues with a female transfer student who has claimed "his seat," leading them to dislike each other. Later that day he's presented with a golden opportunity to clear his family's debt: a private tutoring gig for a wealthy family's daughter, with a wage of five times the market price. He accepts the proposal, but is horrified to discover that the client, Itsuki Nakano, is the girl he confronted earlier. After unsuccessfully trying to get on Itsuki's good side, Uesugi finds out that his problems don't end there: Itsuki is actually a quintuplet, so he must also tutor her sisters--Miku, Yotsuba, Nino, and Ichika--who, despite the very real threat of flunking, want nothing to do with a tutor. However, his family's livelihood is on the line so he pushes on, adamant in his resolve to rid the sisters of their detest for studying and successfully lead them to graduation.